Single-cell RNA sequencing and spatial transcriptomics reveal heterogeneity and key subgroups in ovarian cancer: HOXA1 identified as a potential therapeutic biomarker
This study systematically mapped the single cell map of ovarian cancer. The identified key genes, cell subgroups, and the newly developed STRS prognostic model all showed significant clinical application value. These findings not only deepen the understanding of the pathogenesis of OC, but also provide a theoretical basis for optimizing diagnosis and treatment strategies, thus promoting the transformation from research to clinical practice to better meet the needs of patients.
Authors
- Lianwei LiuXinjun ChenQianghua Xu
- Yaqi Liu (ORCID: https://orcid.org/0000-0003-3401-5473)
- Wangzheqi Zhang (ORCID: https://orcid.org/0009-0008-5312-1806)
- Zhiheng Lin (ORCID: https://orcid.org/0000-0002-9607-6661)
- Leilei Liang (ORCID: https://orcid.org/0000-0001-9719-4478)
- Lei Sun (ORCID: https://orcid.org/0000-0002-8310-1880)
- Li Zhao
- Qian Zhao
- Tao Zhu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Southwest Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Zhejiang Cancer Hospital (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1097/js9.0000000000004904
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 22.24