Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification
Our study elucidates the tumor-suppressive role of GATA4 in regulating lysosomal acidification and epithelial-mesenchymal transition through ubiquitination-dependent mechanisms and histone acetylation modulation. The findings identify GATA4 as a promising therapeutic target and diagnostic marker for ovarian cancer intervention.
Authors
- Zhuxiu Chen
- Xuemei Chen
- Yanqing Geng
- Rufei Gao
- Yidan Ma
- Yan Zhang
- Junlin He
- Fei Han
- Xinyi Mu
- Fangfang Li
- Xin Yin
Institutions
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Genome biology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13059-026-03982-7
- Primary Topic
- Metastasis and carcinoma case studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00