Characterization and anti-inflammatory studies of supramolecular assemblies of chlorogenic acids with metal ions
The findings confirm that complexation with metals (iron and copper) successfully enhances the anti-inflammatory efficacy of chlorogenic acids. The primary mechanism involves the inhibition of the NF-κB pathway. This study provides a novel and efficient strategy for augmenting the bioactivities of natural products and highlights the considerable potential of chlorogenic acid-metal supramolecular assemblies as a promising new class of anti-inflammatory agents.
Authors
- Jiefu Tang (ORCID: https://orcid.org/0009-0008-0463-1498)
- Zi‐xuan Liu
- Lian Zhu (ORCID: https://orcid.org/0000-0002-5846-3185)
- Wei Cai (ORCID: https://orcid.org/0000-0001-6281-5449)
- Han-Xiu Deng
- Jia-Yu Zhang
- Ru-Yue Zhang
- Zhen-Min Zhang
Institutions
- Binzhou Medical University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Shandong University of Aeronautics (CN)
- Hunan University (CN)
- Hunan University of Science and Engineering (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fphar.2025.1726226
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hunan Provincial Science and Technology Department
- Scientific Research Foundation of Hunan Provincial Education Department