Solithromycin mitigates Prevotella intermedia–induced methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia by enhancing alveolar macrophage function
SOL protects by activating alveolar macrophages and promoting TNF-related responses, suggesting a novel immunomodulatory role for SOL in host defense against exacerbation of MRSA-VAP by <i>P. int.</i> sup.
Authors
- Nobuyuki Ashizawa (ORCID: https://orcid.org/0009-0005-9468-6051)
- K. Fukushima (ORCID: https://orcid.org/0000-0001-5942-0710)
- Tatsuro Hirayama (ORCID: https://orcid.org/0000-0001-8554-3482)
- Noriho Sakamoto (ORCID: https://orcid.org/0000-0002-7577-476X)
- Shotaro Ide (ORCID: https://orcid.org/0000-0001-7872-8147)
- H. Mukae
- Mariko Naito (ORCID: https://orcid.org/0000-0003-0769-7747)
- Naoki Iwanaga (ORCID: https://orcid.org/0000-0002-0680-390X)
- Masataka Yoshida (ORCID: https://orcid.org/0000-0002-5621-955X)
- Kazuaki Takeda (ORCID: https://orcid.org/0000-0003-1611-4435)
- Kosuke Kosai
- Katsunori Yanagihara
- Takahiro Takazono
Institutions
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fcimb.2026.1723186
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- FUJIFILM Toyama Chemical