Inhibition of the p38/JNK MAPK pathway mediated by circadian rhythm genes: Study of the mechanism of Linggan Wuwei Jiangxin decoction in the treatment of COPD
LGWWJXD reduced inflammation in rat lungs, protected against apoptosis, and reduced pathological lung damage to help improve lung function. The potential active ingredients in LGWWJXD, including Asarinin, 6-Shogaol, and Isoliquiritigenin, may regulate the expression of circadian rhythm-related genes, inhibited the p38/JNK MAPK pathway, and jointly suppressed the inflammatory response in combination with arginine biosynthesis and purine metabolism pathways. It lays a scientific foundation for the clinical treatment of COPD with LGWWJXD.
Authors
- Kaiyu Zhu (ORCID: https://orcid.org/0000-0001-7364-1923)
- Kairui Zhang
- B. N. Xiao
- Jinɡjinɡ Li (ORCID: https://orcid.org/0000-0002-7526-5308)
- Meng Chen (ORCID: https://orcid.org/0009-0009-5032-4429)
- Ye Wen (ORCID: https://orcid.org/0000-0002-9119-3738)
- Fang Huang
- Kai Chang (ORCID: https://orcid.org/0000-0002-4677-2466)
- Hong Xing
- Zhuang Huang (ORCID: https://orcid.org/0000-0003-4666-3267)
- Rui Qian (ORCID: https://orcid.org/0009-0009-2324-0887)
- Pengyu Chen
- Shihao Li
- Ping Huang
- Qiong Wang
- Huangen Kou
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.jep.2026.121349
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00