High-Throughput Screening of FDA-Approved Drugs for Antibacterial and Antibiofilm Activities Against Multidrug-resistant <i> <i>Pseudomonas aeruginosa</i> </i>
By using a systematic screening-prioritization-safety filtering framework, this study identified rifabutin and nafamostat as prioritized repurposing candidates against MDR <i>P. aeruginosa</i> , highlighting the importance of early safety evaluation in antimicrobial drug repurposing.
Authors
- C. Chen
- Hongfu Li
- Sitong Guo
- Bo Liu
Institutions
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- Artificial Intelligence in Medicine (Canada) (CA)
- Macao Polytechnic University (MO)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1021/acsomega.5c12226
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00