Sophora tonkinensis reprograms tumor-associated macrophages to M1-like phenotype and exerts anti-hepatocellular carcinoma effects
STE reprograms TAMs via the JAK1/STAT1 axis and exhibits robust antitumor activity, underscoring its promise as a natural, macrophage-targeted immunotherapeutic that warrants further investigation for integration into cancer treatment strategies.
Authors
- Zongliang Lu
- Caiping He
- Lu Liu
- Jincai Wen
- Xiaoyan Zhan
- Xianling Wang
- Ang Huang
- Zhaofang Bai
- Jun Zhao
- Xiaoyan Chen
- Xiaohe Xiao
Institutions
- Chinese PLA General Hospital (CN)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1016/j.molimm.2026.02.003
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00