Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy
This integrative multi-omics analysis revealed distinct imaging and proteomic mechanisms of genetically proxied β1-blockers in HHD and HCM, providing genetic evidence for differential therapeutic responses and highlighting molecular targets for precision cardiovascular therapy.
Authors
- Jiangjiang Liu
- Zhe Chen (ORCID: https://orcid.org/0000-0002-8654-9218)
- Shuang Li (ORCID: https://orcid.org/0000-0002-6828-5925)
- Yifan Tang
- Bin Wang
- Jiaxuan Wu
- Liangbin Pan
- Haitao Ma
- Kai Xie
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s12916-026-04691-5
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00