Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation
This study provides structural and experimental evidence for the target selection, structural optimization, and molecular mechanism of RSV in the treatment of POI.
Authors
- Mujun Li (ORCID: https://orcid.org/0000-0001-5216-2990)
- Feiwen Li
- Weilong Peng (ORCID: https://orcid.org/0000-0001-5820-889X)
- F Liu
- Hongfan Ding
- Huimei Wu (ORCID: https://orcid.org/0009-0006-3957-3510)
- Zhaoyang Yu
- Yingqi Nong
- Wenjuan Liu
- Chang Liu
- Xiqian Zhang
- Xiaoyin Lv
- Jiao Wang
- Tao Zhang
Institutions
- Guangxi Medical University (CN)
- Chinese University of Hong Kong (HK)
- Guangzhou University (CN)
- Hegang People's Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Guangdong Province Women and Children Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1097/js9.0000000000004655
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00