Divergent CD45+ immune landscapes shape the lung tumor microenvironment
Distinct CD45<sup>+</sup> immune landscapes, characterized by inflammatory suppression in LLC1 and metabolic adaptation in Kras<sup>LA2</sup> tumors, shape lung tumor biology. This atlas identifies genotype-specific immune vulnerabilities with potential relevance for precision immunotherapy in non-small cell lung cancer.
Authors
- S. Guenther
- Kati Turkowski (ORCID: https://orcid.org/0000-0002-8455-8268)
- Bastian Eul
- Soni Savai Pullamsetti (ORCID: https://orcid.org/0000-0003-0440-8831)
- Mario Looso
- Thorsten Stiewe (ORCID: https://orcid.org/0000-0003-0134-7826)
- Friedrich Grimminger (ORCID: https://orcid.org/0000-0001-8725-6276)
- Werner Seeger
- Rajkumar Savai
- A Weigert
- René Wiegandt
- Selma Dizdarević
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- University of Mannheim (DE)
- Justus-Liebig-Universität Gießen (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Lung Institute (US)
- Max Planck Institute for Heart and Lung Research (DE)
- German Center for Lung Research (DE)
- Molecular Oncology (United States) (US)
- Cardio-Pulmonary Institute (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1765833
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00