Vaginal Cancer, Version 2.2026, NCCN Clinical Practice Guidelines In Oncology
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Vaginal Cancer outline the recommended diagnostic workup, staging considerations, and treatment options for this rare malignancy. Because vaginal cancer is uncommon and shares many biologic and clinical characteristics with cervical cancer, several management recommendations, particularly systemic therapy, are extrapolated from evidence and practices established for cervical cancer. This guideline excerpt summarizes key components of management, including diagnostic evaluation and workup, principles of staging, pathology considerations, radiation therapy principles, and primary treatment recommendations for both early-stage and advanced disease. It also details approaches to manage relapses, including locoregional recurrence and distant metastases, and provides an in-depth overview of systemic therapy recommendations for vaginal cancer.
Authors
- Emma L. Barber (ORCID: https://orcid.org/0000-0002-8111-0767)
- Robert Giuntoli (ORCID: https://orcid.org/0000-0003-1232-673X)
- Ritu Salani (ORCID: https://orcid.org/0000-0002-8907-0966)
- Gina Mantia-Smaldone (ORCID: https://orcid.org/0000-0001-8223-3059)
- Nicole R. McMillian
- Stefanie Ueda (ORCID: https://orcid.org/0000-0002-4359-0966)
- Emily Wyse (ORCID: https://orcid.org/0000-0002-9657-0870)
- Scott M. Schuetze (ORCID: https://orcid.org/0000-0002-7167-4163)
- Jayanthi Lea (ORCID: https://orcid.org/0000-0002-8657-4309)
- Stéphanie Gaillard (ORCID: https://orcid.org/0000-0002-2174-3693)
- Susana M. Campos (ORCID: https://orcid.org/0000-0001-9672-473X)
- Nita K. Lee (ORCID: https://orcid.org/0000-0002-7384-9975)
- Brooke E. Howitt (ORCID: https://orcid.org/0000-0002-0309-6680)
- Rebecca C. Arend (ORCID: https://orcid.org/0000-0003-2108-3426)
- Kari Kendra (ORCID: https://orcid.org/0000-0001-5936-6689)
- Junzo Chino (ORCID: https://orcid.org/0000-0002-3633-9685)
- Pamela T. Soliman (ORCID: https://orcid.org/0000-0002-8784-9212)
- Gretchen Glaser (ORCID: https://orcid.org/0000-0001-9413-316X)
- Renata R. Urban (ORCID: https://orcid.org/0000-0001-8967-3794)
- David K. Gaffney (ORCID: https://orcid.org/0000-0002-5752-1611)
- Kerry J. Rodabaugh (ORCID: https://orcid.org/0000-0002-8884-7083)
- Mirna Podoll
- Andrea Mariani
- John O. Schorge
- Christine M. Fisher (ORCID: https://orcid.org/0000-0001-9629-5998)
- Jean Siedel (ORCID: https://orcid.org/0000-0002-2596-3634)
- Shari Damast (ORCID: https://orcid.org/0000-0001-9030-0872)
- Scott Glaser (ORCID: https://orcid.org/0000-0002-0756-9449)
- Christa Irene Nagel (ORCID: https://orcid.org/0000-0001-6454-6246)
- Rebecca Brooks
- Lisa M. Landrum (ORCID: https://orcid.org/0000-0002-4010-6833)
- Peter J. Frederick
- Hye Sook Chon
- Nadeem R Abu-Rustum
- Sudha R. Amarnath (ORCID: https://orcid.org/0000-0002-0852-3135)
- Kristin Bradley
- Vaishnavi Sambandam
- Larissa Nekhlyudov
- Chika Nwachukwu
- Marta Ann Crispens
- David Mutch
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- Duke Medical Center (US)
- University of Colorado Cancer Center (US)
- Patient Advocate Foundation (US)
- Dana-Farber Brigham Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Duke Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2026-02-09
- DOI
- https://doi.org/10.6004/jnccn.2026.0011
- Primary Topic
- Academic Publishing and Open Access
- Type
- article
- Field-Weighted Citation Impact
- 0.00