Exploring the toxicological impact of N-nitrosodimethylamine (NDMA) exposure on bladder urothelial carcinoma (BLCA) through network toxicology, machine learning, and multi-dimensional bioinformatics analysis
NDMA likely promotes BLCA through multi-target and multi-pathway mechanisms. The identified core genes serve as potential diagnostic biomarkers, and the proposed AOP provides a theoretical basis for environmental risk assessment and targeted intervention strategies.
Authors
- Xixing Wang (ORCID: https://orcid.org/0000-0003-2444-7248)
- Jiajia Liu (ORCID: https://orcid.org/0000-0003-0326-1057)
- Y Y Liu
- Gao Yu (ORCID: https://orcid.org/0009-0007-6430-0992)
- Zhiyao Shi (ORCID: https://orcid.org/0000-0002-0838-1448)
- Limin Wang
- Xiaokun Yang
Institutions
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1007/s12672-026-04564-6
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00