Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism
TRT during LT selectively enhances skeletal muscle glycolysis, identifying glycolic activation as the dominant metabolic adaptation in this mechanistic study. By increasing glycolytic flux under calorie restriction, TRT may produce efficient ATP generation while conserving amino acids, supporting muscle and bone preservation and improving aerobic and cardiometabolic function in older men with obesity and hypogonadism.
Authors
- NICOLA NAPOLI
- Alessandra Celli (ORCID: https://orcid.org/0009-0000-2186-0892)
- Clifford Qualls (ORCID: https://orcid.org/0000-0002-9110-3181)
- Yoann Barnouin (ORCID: https://orcid.org/0000-0002-3497-9099)
- Viola Viola (ORCID: https://orcid.org/0000-0002-4557-816X)
- Maria Liza Duremdes Nava
- Dennis T. Villareal
- Nagireeddy Putluri
- Reina Armamento-Villareal
- Marlene Aguilar
Institutions
- Michael E. DeBakey VA Medical Center (US)
- University of New Mexico (US)
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Campus Bio Medico University Hospital (IT)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fendo.2025.1719749
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Cancer Prevention and Research Institute of Texas