Persistent CD8+ T cell-driven immune dysregulation despite normalized CD4+ T cell recovery in ART-treated people living with HIV
Persistent CD8<sup>+</sup> T cell activation reflects a distinct immunological state marked by CD4/CD8 ratio inversion, cell senescence, exhaustion, and systemic inflammation. This immune profile may help identify individuals who warrant closer immunological monitoring for non-AIDS complications and may inform future studies aimed at modulating CD8<sup>+</sup> T cell-driven immune dysregulation to improve long-term immune restoration.
Authors
- Jun He (ORCID: https://orcid.org/0000-0002-1479-285X)
- Hui Wu (ORCID: https://orcid.org/0000-0002-3068-3805)
- Xiaorui Li (ORCID: https://orcid.org/0000-0003-0302-502X)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-8163-9716)
- Yiyao Hu
- Jiaye Liu (ORCID: https://orcid.org/0000-0003-4434-3120)
- Yinsong Luo
- Lingyun Ge
- Yun He
Institutions
- Chinese PLA General Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Children's Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1735779
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00