Investigation of the Anticancer Effects and Senescence Induction of Hesperetin Combined with Cisplatin in Hepatocellular Carcinoma and Embryonic Fibroblast Cell Lines
These results suggest that HST and Cisp co-treatment synergistically reduces cancer cell viability while protecting normal fibroblasts from senescence, supporting its potential as a co-chemotherapeutic agent in HCC treatment, while also serving as a protective agent against senescence in healthy tissues.
Authors
- Rumiyati Rumiyati (ORCID: https://orcid.org/0000-0002-6969-0359)
- Mila Hanifa (ORCID: https://orcid.org/0000-0003-0935-2363)
- Riris Istighfari Jenie (ORCID: https://orcid.org/0000-0002-0230-6260)
- Kato Jun-ya
- Adam Hermawan (ORCID: https://orcid.org/0000-0001-5851-3691)
- Anif Nur Artanti (ORCID: https://orcid.org/0000-0003-0269-8249)
Institutions
- Sebelas Maret University (ID)
- Universitas Gadjah Mada (ID)
- Nara Institute of Science and Technology (JP)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2026-02-01
- DOI
- https://doi.org/10.31557/apjcp.2026.27.2.557
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lembaga Pengelola Dana Pendidikan