Timing of Secondary Palate Fusion in Human Embryos and Fetuses
These findings refine the timeline of human secondary palate development. Importantly, identifying this critical developmental window suggests that current guidelines for administering medications during early pregnancy should be reevaluated, as drug exposure during this sensitive period may increase the risk of palatal malformations.
Authors
- Roelof‐Jan Oostra (ORCID: https://orcid.org/0000-0002-2452-8307)
- R. Hemke
- Jaco Hagoort (ORCID: https://orcid.org/0000-0002-8324-5390)
- Karl Jacobs (ORCID: https://orcid.org/0000-0002-7701-9370)
- Bernadette Simone de Bakker
- Visser Sl
- Yousif Dawood
- Corstiaan Cornelis Breugem
- Eva Pajkrt
- Jermo Hanemaaijer‐van der Veer
- Jess Johanna Peters
- Puck Pauline Mulder
Institutions
- Academic Center for Dentistry Amsterdam (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Birth Defects Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/bdr2.70029
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers