Serum neurofilament light chain and glial fibrillary acidic protein predicting multiple sclerosis after clinically isolated syndrome
Our study found that serum NfL outperformed GFAP in predicting early MS diagnoses after CIS. Baseline NfL, together with HLA-DRB1*15:01 status, provides robust early risk stratification for MS after CIS, whereas GFAP and anti-EBNA1 titres add limited prognostic value. Additional immunological and imaging markers are essential to further refine predictive models.
Authors
- Andrei N. Tintu (ORCID: https://orcid.org/0000-0002-5648-1400)
- J. van Rooij
- Luisa Agnello (ORCID: https://orcid.org/0000-0003-3458-0421)
- M Ciaccio
- Barry Koelewijn-van Vliet
- Jens Kuhle
- Cato E A Corsten
- Beatrijs Wokke
- Ana M Marques
- Marie-José Melief
- Veerle S A Geraedts
- Joost Smolders
Institutions
- Netherlands Institute for Neuroscience (NL)
- Erasmus MC (NL)
- University Hospital of Basel (CH)
- Department of Biomedicine Basel (CH)
- University of Palermo (IT)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1007/s00415-026-13667-7
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00