Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease
This study identified specific DNA methylation sites associated with TMAO and related metabolites. These epigenetic changes may contribute to CVD risk through multiple pathways. Future research should validate these findings and explore their clinical implications.
Authors
- Jie Yao (ORCID: https://orcid.org/0000-0002-7640-4840)
- Zeneng Wang
- Xinmin S. Li (ORCID: https://orcid.org/0000-0003-4946-4271)
- Mandy Fretts
- Soyoung Lee (ORCID: https://orcid.org/0000-0002-8758-252X)
- W. H. Wilson Tang
- Yongmei Liu
- Chao-Qiang Lai
- Bruce M. Psaty
- M B Matthew Budoff
- José M. Ordovás
- Durda Peter
- Kent D. Taylor
- Jiantao Ma
- Meng Wang
- Russell P. Tracy
- Nona Sotoodehnia
- Joseph A. DiDonato
- Jerome I. Rotter
- David S. Siscovick
- Stanley L. Hazen
- Jennifer A. Brody
- Dariush Mozaffarian
- Xiuqing Guo
Institutions
- University of Vermont (US)
- Tufts University (US)
- New York Academy of Medicine (US)
- Cleveland Clinic (US)
- Duke University (US)
- University of Washington (US)
- UCLA Medical Center (US)
- Jean Mayer Human Nutrition Research Center on Aging (US)
- Harbor–UCLA Medical Center (US)
- University of Virginia (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13148-026-02060-w
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00