Neuroprotective effects of semaglutide targeting the left temporal lobe in adults with overweight or obesity: A 24‐week multimodal neuroimaging study
A 24-week semaglutide intervention induces significant neurobiological remodelling in the left temporal lobe of adults with overweight or obesity. These central effects are independent of the drug's systemic metabolic improvements, offering new evidence for its potential neuroprotective role.
Authors
- Tiange Sun (ORCID: https://orcid.org/0000-0003-1955-5121)
- Zhiyan Yu (ORCID: https://orcid.org/0000-0001-8282-6356)
- Xiangming Lin
- F X Meng
- Shufei Zang
- Yue Li
- Rui Zhang
- Xiang Ao
Institutions
- Fudan University (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1111/dom.70524
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Pudong New Area Health Commission