A General Electrochemical C(sp <sup>3</sup> )–H Amination of Hydrocarbons Suitable for Inactive Alkanes, Alkenes and Alkynes
The first example of the electrochemical C(sp<sup>3</sup>)-H amination of inactive hydrocarbons with sulfoximines was reported. We proposed the concept of an NH<sub>3</sub>-induced electrochemical reaction for the first time. Although the electrochemical C(sp<sup>3</sup>)-H functionalization of inactive linear hydrocarbons is difficult (especially for alkynes), this reaction is suitable for both linear and cyclic hydrocarbons; the reaction is advantageous because it is green, generates minimal waste (with H<sub>2</sub> as the only byproduct), proceeds without transition metal and external oxidant, and requires mild reaction conditions.
Authors
- Ziru Xu (ORCID: https://orcid.org/0000-0002-4480-5391)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Hui Gao
- Pei-Long Wang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Huaibei Normal University (CN)
- Ocean University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1021/acs.orglett.6c00002
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00