Age-driven shifts in T and NK cell responses amplify inflammation and coagulopathy during viral infection in mice and humans
These findings demonstrate that advanced age profoundly alters antiviral immune responses, shifting immunity away from effective antigen-specific T cell responses toward inflammatory and innate pathways that contribute to immune-mediated pathology. The results highlight the importance of modeling advanced aging in preclinical studies and suggest that age-dependent immune imbalance may underlie increased inflammation, coagulopathy, and mortality during viral infection in both mice and humans.
Authors
- Lam T. Khuat (ORCID: https://orcid.org/0000-0002-4223-8805)
- Logan V. Vick (ORCID: https://orcid.org/0009-0006-9778-0120)
- Nicole Baumgarth (ORCID: https://orcid.org/0000-0002-2891-4483)
- Cordelia Dunai
- Ian R. Sturgill (ORCID: https://orcid.org/0000-0003-1869-6344)
- Robert J. Canter (ORCID: https://orcid.org/0000-0002-3331-5418)
- A. Merleev
- Craig Collins
- William J. Murphy
- Eunju (April) Choi
- Emanual Maverakis
- Jonathan Lam
- Dan L. Longo
Institutions
- Harvard University (US)
- Johns Hopkins University (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Sylvester Comprehensive Cancer Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1712726
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00