Long-term left ventricular assist device support reinforces detrimental immunological effects
This cross-sectional observational study revealed that long-term (≥36 months) LVAD support may contribute to detrimental effects on the immune system in comparison to short-term LVAD support. The long-lasting LVAD support may influence DCs, NK cells and B-cells that show a progression of cellular changes.
Authors
- Kristin Klaeske (ORCID: https://orcid.org/0000-0002-8873-6391)
- Eva Katharina Messer (ORCID: https://orcid.org/0009-0005-6420-3549)
- Michal Nozdrzykowski
- Alexey Dashkevich (ORCID: https://orcid.org/0000-0001-6166-7210)
- Sandra Eifert
- M T H Dieterlen
- Malina Sauskat
- Michael A. Borger
- Joanna Jozwiak-Nozdrzykowska
Institutions
- Leipzig Heart Institute (DE)
- Helios Park-Klinikum Leipzig (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fimmu.2026.1705980
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Herzstiftung