Identification of BRCA1 and BRCA2 Germline Mutations in Female Breast Cancer Patients Using Next Generation Sequencing
BRCA1 and BRCA2 germline profiling based on next-generation sequencing technology among Egyptian breast cancer female patients revealed 135 germline variations -104 intronic and 31 exonic, respectively. Among the exonic variants; 13 were newly reported mutations. Hence further study is required to enhance mutational analysis which may benefit clinical system.
Authors
- Mohamed Emam Sobeih
- Maha Abo Hashim
- Menha Swellam (ORCID: https://orcid.org/0000-0002-7104-7194)
- Amira M. Nageeb (ORCID: https://orcid.org/0000-0002-5181-7438)
- Magdy E. Mahfouz
- M. W. Sh. Mahmoud
- Lobna R Ez ElArab
- Mohamed K Khalifa
- Madyha H Mahmoud
- Aliaa Alisslam I A Alshazly
Institutions
- Ain Shams University (EG)
- Kafrelsheikh University (EG)
- Research Institute of Ophthalmology (EG)
- Agricultural Genetic Engineering Research Institute (EG)
- National Research Centre (EG)
- Children Cancer Hospital (EG)
- Biotechnology Research Institute (CN)
- Jazan University (SA)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2026-02-01
- DOI
- https://doi.org/10.31557/apjcp.2026.27.2.575
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Development Fund