Cortical Oscillations as an Endophenotype Mediating ApoE-ε2 Effects on Poststroke Functional Status
The mediation analysis results suggests that ApoE-ε2 supports a pro-repair environment, which may translate into more favorable cortical dynamics after stroke. Cortical oscillatory activity may be considered as an endophenotype that mediates the effects of ApoE-ε2 on functional outcome and could potentially be leveraged as a biomarker to develop personalized interventions targeting stroke recovery.
Authors
- SC Cramer
- Kathie J. Ngo (ORCID: https://orcid.org/0000-0002-2092-410X)
- Anne Schwarz (ORCID: https://orcid.org/0000-0001-8943-5673)
- Célia Delcamp (ORCID: https://orcid.org/0000-0002-2303-0769)
- Darice Y. Wong
- Brent L. Fogel
- Ramesh Srinivasan
Institutions
- University of California, Los Angeles (US)
- University of California, Irvine (US)
- University of California System (US)
- Irvine University (US)
- Solve ME/CFS Initiative (US)
- Cognitive Research (United States) (US)
Publication Details
- Journal
- Stroke
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1161/strokeaha.125.054238
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00