Advancements in RNA-based therapies from bench to bedside
Abstract RNA research has advanced rapidly, becoming a key component of modern therapeutics. This review outlines key milestones and innovations from antisense oligonucleotides and RNA interference to mRNA therapies and aptamers that have enabled targeted treatments for diverse diseases. The success of COVID-19 mRNA vaccines highlighted the remarkable clinical potential of RNA-based technologies. Emphasis is placed on delivery technologies, landmark approvals, and ongoing trials shaping the future of RNA-based medicine.
Authors
- Rakesh Kumar Tekade (ORCID: https://orcid.org/0000-0002-3024-3148)
- Muktika Tekade
- Sreeharsha Nagaraja
- Azad Bharti
- Amrita Singh
Institutions
- Lovely Professional University (IN)
- Department of Pharmaceuticals (IN)
- King Faisal University (SA)
Publication Details
- Journal
- npj Drug Discovery.
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1038/s44386-025-00037-y
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Pharmaceutical Education and Research, Ahmedabad
- Department of Biotechnology, Ministry of Science and Technology, India
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
- Science and Engineering Research Board