Tamoxifen-loaded TPGS-PLGA nanoplatform for breast cancer therapy: insights into drug delivery, distribution, treatment efficacy, and ultrasound/photoacoustic imaging
The developed TAM@TPGS-PLGA-NPs demonstrated enhanced drug release in the tumor microenvironment, significantly improved cytotoxicity, and excellent biocompatibility compared to the free drug. These findings indicate their strong potential for tumor-targeted breast cancer therapy with reduced systemic toxicity and enhanced therapeutic efficacy.
Authors
- Nandini Vinodrao Randhave
- Vikas Kumar (ORCID: https://orcid.org/0000-0001-9984-0437)
- Nishi Agrawal
- Komal Rani
- Dipali Patil
- Aseem Setia
- Madaswamy S Muthu
- Nidhi Verma
- Vaishali
Institutions
- Guru Ghasidas Vishwavidyalaya (IN)
- Indian Institute of Technology BHU (IN)
Publication Details
- Journal
- Nanomedicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1080/17435889.2026.2624743
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00