KMT2B-related disorders in Austria: clinical features and long-term outcome after deep brain stimulation
Our long-term data underscore the progressive but heterogeneous course of <i>DYT-KMT2B</i>. GPi DBS offers durable clinical benefits, particularly when initiated before loss of ambulation. Early surgical intervention and multidisciplinary management are essential to optimize long-term outcomes.
Authors
- A. Langer (ORCID: https://orcid.org/0000-0001-9932-0474)
- P Mahlknecht
- Anna Lena Eberl
- Wolfgang M. Schmidt (ORCID: https://orcid.org/0000-0002-6944-2443)
- S. M. Boesch
- Katherina Mair
- Michael Zech
- Sandy Siegert
- Elisabetta Indelicato
- Anna Hussl
Institutions
- Innsbruck Medical University (AT)
- Helmholtz Zentrum München (DE)
- Centre for Movement Disorders (CA)
- Institute of Human Genetics (PL)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fneur.2026.1727854
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00