<scp>TREM2</scp> Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury
Our study suggests that TREM2 promotes myelin debris clearance but exacerbates chronic inflammation and fibrosis after SCI. These findings underscore the promise of TREM2 as a target for developing effective treatment strategies for SCI.
Authors
- Zhonghan Wu
- L H Cheng
- Yixue Hu
- Fei Yao (ORCID: https://orcid.org/0000-0003-2729-016X)
- Xuyang Hu
- Ziyu Li
- Shuisheng Yu
- D S Tian
- J H Jing
- Yiyang Mu
- Mengdi Zhang
- Linhan Yang
- Yan Jiang
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70777
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00