Mediating Cross-Talk: How Uterus-derived Extracellular Vesicles Influence Early Embryo Development and Implantation

Blastocyst formation represents an essential requirement for subsequent implantation.Successful embryo implantation depends on adequate endometrial receptivity and appropriate embryo-maternal communication.Uterus-derived extracellular vesicles(EVs), as biological nanoscale particles carrying non-coding RNAs(nc-RNAs), DNAs, proteins and lipids, play a crucial role in promoting cellular interactions and regulating maternal-fetal dialogue.