Circulating ex-Trm CD8 + T cells with skin-homing/chemoattraction phenotype are associated with disease severity in atopic dermatitis
Circulating CD8<sup>+</sup> ex-Trm cells with skin-homing properties may contribute to AD progression by reseeding distant skin sites and sustaining inflammation, whereas CD4<sup>+</sup> ex-Trm cells may remain preferentially retained within inflamed skin. These findings identify circulating CD8<sup>+</sup> ex-Trm cells as potential biomarkers of disease severity and disease dissemination.
Authors
- Diana Bautista (ORCID: https://orcid.org/0000-0002-0817-2718)
- Consuelo Romero-Sánchez
- Maria F. Ordóñez-Rubiano
- Miguel Parra
Institutions
- Universidad El Bosque (CO)
- Hospital Militar Central (CO)
- The FRAM Centre (NO)
- Hospital Central Militar (MX)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.3389/fmed.2026.1656289
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad El Bosque