Collagenase Inhibitory Activities of Plants: A Review

ABSTRACT Background Aging is a dynamic, gradual, and irreversible biological process, with skin aging characterized by dermal thinning, a progressive loss of collagen fibers, and a reduction in elastic fibers, ultimately leading to lost skin elasticity and firmness. Reducing damage to cellular components over time and enhancing tissue morphology helps maintain youthful‐looking skin. Even though skin aging is inevitable, skincare formulations could help delay its progression to some extent. There is a steady increase in public awareness about the health benefits of plant‐derived and other natural ingredients in skincare formulations, as well as concerns about the risks of synthetic chemicals. The cosmetics industry is paying more attention to natural products as a result. Aim This review aims to provide a concise overview of current research on natural collagenase inhibitors and their relevance in anti‐aging skincare. Method Given that natural collagenase inhibitors are crucial in the development of anti‐aging skincare products, this review aims to provide a concise overview of the current literature on the potential collagenase inhibitory activities of herbs, fruits, and marine algae, as well as their secondary phytoconstituent compounds and potential applications. Conclusion The compiled information provides a valuable foundation for further in‐depth research aimed at supporting the development of plant‐based skincare formulations.