Tumour mutation burden drives survival outcomes in pancreatic ductal adenocarcinoma and enables noninvasive prediction via dual-layer spectral CT
High TMB in patients with PDAC portends better PFS, particularly those receiving combination immunotherapy. A clinically applicable TMB cutoff of 5 mut/Mb was identified, stratifying patients into biologically distinct low- and high-TMB prognostic groups. DLCT-derived pancreatic phase normalized iodine concentration emerged as a superior noninvasive TMB biomarker compared to conventional imaging parameters.
Authors
- Meicheng Chen (ORCID: https://orcid.org/0000-0002-7604-0776)
- Jie Liu (ORCID: https://orcid.org/0000-0002-9297-7729)
- Mingjie Chen (ORCID: https://orcid.org/0000-0002-5197-5129)
- Siya Shi
- Yanji Luo
- S T Feng
- Jiadan Luo
- Zujiang Shi
- Liqin Wang
- Luyong Wei
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Insights into Imaging
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13244-026-02216-5
- Primary Topic
- Advanced X-ray and CT Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province