LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR<b>-</b>345<b>-</b>3p/Bak and miR<b>-</b>708<b>-</b>5p/Bim pathways.

AK154753 is upregulated in acute renal IRI and promotes apoptosis by suppressing miR-345-3p and miR-708-5p, thereby upregulating Bak and Bim, and participates in the initiation and progression of acute renal IRI.

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Publication Details

Journal
PubMed
Published
2025-10-28
DOI
https://doi.org/10.11817/j.issn.1672-7347.2025.240687
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
0.00
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article

LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR-345-3p/Bak and miR-708-5p/Bim pathways.

Ji Xi, Yunzhen Deng, Chongjian Tang, Y Hanna Wen et al.
PubMed
Cancer-related molecular mechanisms research
article

LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR-345-3p/Bak and miR-708-5p/Bim pathways.

Ji Xi, Yunzhen Deng, Chongjian Tang, Y Hanna Wen, S. Li, Junxiang Chen, Kaiting Zhuang, Yi He
article en

Abstract

AK154753 is upregulated in acute renal IRI and promotes apoptosis by suppressing miR-345-3p and miR-708-5p, thereby upregulating Bak and Bim, and participates in the initiation and progression of acute renal IRI.

PubMedVol. 50(10)
Central South University (CN), Second Xiangya Hospital of Central South University (CN)
Good health and well-being
Openalex Percentile: Top 31%
Cancer-related molecular mechanisms research
DOIOpen Access PDFOpenAlex
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LncRNA AK154753 mediates the development of acute kidney ischemia reperfusion injury via the miR<b>-</b>345<b>-</b>3p/Bak and miR<b>-</b>708<b>-</b>5p/Bim pathways. — Ji Xi, Yunzhen Deng, et al. · PubMed (2025) | TGRS Research Map | TGRS