Whole Heart Dose Parameters Predict Severe Arrhythmias After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer: A Competing Risk Analysis of 358 Patients

Grade ≥ 3 cardiac arrhythmia associated with thoracic radiation occurs in 16.7% of ESCC patients undergoing nCRT within a median time of 13 months. The radiation dose exposure of the supraventricular cardiac conduction system is not associated with increased cardiac arrhythmia. Specific arrhythmia subtypes exhibited differential associations with distinct dose-volume parameters of whole heart irradiation.

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Publication Details

Journal
Cancer Medicine
Published
2026-02-01
DOI
https://doi.org/10.1002/cam4.71610
Primary Topic
Esophageal Cancer Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Whole Heart Dose Parameters Predict Severe Arrhythmias After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer: A Competing Risk Analysis of 358 Patients

C. Xu, Gang Cai, Chen Jiayi, Shengguang Zhao et al.
Cancer Medicine
Esophageal Cancer Research and Treatment
article

Whole Heart Dose Parameters Predict Severe Arrhythmias After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer: A Competing Risk Analysis of 358 Patients

C. Xu, Gang Cai, Chen Jiayi, Shengguang Zhao, M. Wang, Wei‐Xiang Qi, Xunmei Yang, Biao Yu
article en

Abstract

Grade ≥ 3 cardiac arrhythmia associated with thoracic radiation occurs in 16.7% of ESCC patients undergoing nCRT within a median time of 13 months. The radiation dose exposure of the supraventricular cardiac conduction system is not associated with increased cardiac arrhythmia. Specific arrhythmia subtypes exhibited differential associations with distinct dose-volume parameters of whole heart irradiation.

Cancer MedicineVol. 15(2)
Ruijin Hospital (CN), Shanghai Genon Biological Products (China) (CN), Linyi People's Hospital (CN), The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Shanghai Municipal Health Commission, National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 63%
Esophageal Cancer Research and Treatment
DOIOpen Access PDFOpenAlex
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Whole Heart Dose Parameters Predict Severe Arrhythmias After Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Cancer: A Competing Risk Analysis of 358 Patients — C. Xu, Gang Cai, et al. · Cancer Medicine (2026) | TGRS Research Map | TGRS