Combination Effects of Clindamycin and Benzoyl Peroxide Against <i>Cutibacterium acnes</i>
This study aimed to evaluate the clinical efficacy of combination therapy with clindamycin and benzoyl peroxide in treating acne vulgaris. We assessed the antimicrobial susceptibility of Cutibacterium acnes isolates obtained from these patients. In addition, the potential risk of C. acnes developing resistance to clindamycin and benzoyl peroxide following exposure was investigated in vitro. We analyzed 182 C. acnes isolates from patients with acne to evaluate the clindamycin susceptibility and resistance determinants and to examine the association between topical clindamycin use and resistance. We also tested the resistance frequency of C. acnes to clindamycin monotherapy and clindamycin/benzoyl peroxide combination therapy in vitro. The clindamycin resistance rates in the clindamycin/benzoyl peroxide and clindamycin monotherapy groups were 22.9% and 46.7%, respectively. The combination group showed a significantly lower clindamycin resistance rate (p < 0.05). Under clindamycin monotherapy, resistant strains emerged at a frequency of 8.1 × 10<sup>-8</sup> to 8.7 × 10<sup>-8</sup>, whereas no resistant strains were detected under clindamycin/benzoyl peroxide combination conditions. The combination of clindamycin and benzoyl peroxide effectively suppressed the emergence of clindamycin-resistant C. acnes.
Authors
- Utako Kimura (ORCID: https://orcid.org/0000-0002-9217-1805)
- Emi Nakazaki
- Saori Murakami
- Nobukazu Hayashi
- Takae Yasuda
- Mayumi Nomoto
- Mie Kakuta
- Hidemasa Nakaminami (ORCID: https://orcid.org/0000-0003-2889-8257)
- Chikage Takeo
- Yuki Horiuchi (ORCID: https://orcid.org/0000-0003-2191-5405)
- Kazuha Kasugai
- Yuko Fukano
- Tokihiko Shimada
- Waka Ishida (ORCID: https://orcid.org/0000-0002-3217-3059)
- Noriko Tanaka (ORCID: https://orcid.org/0000-0002-4653-7044)
- Masako Watanabe
- Chiaki Murase
- Junichi Sugai
- Miwa Kobayashi
- Ikue Hou
- Hiroko Ichimiya
- Koyo Yoshihara
- Yoshiki Miyachi
- Akiko Ishii
- Masumi Kohno
- Shoji Seyama
- Yoshitsune Ban
Institutions
- Obayashi (Japan) (JP)
- Suzuki (Japan) (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Kiryu University (JP)
- Juntendo University (JP)
- Niigata University of Rehabilitation (JP)
- Ehime Medical Center (JP)
- Akebono Clinic (JP)
- Kanagawa Rehabilitation Hospital (JP)
- Okayama Psychiatric Medical Center (JP)
- Ichinomiya Kenshin College (JP)
- Kagoshima City Hospital (JP)
- Sleep Comprehensive Care Clinic Yoyogi (JP)
- Ono Clinic (JP)
- Nitobe Memorial Nakano General Hospital (JP)
- Aichi Cancer Center (JP)
- Minamiaoyama Eye Clinic (JP)
- Skin Research Center (FR)
- Meguro Parasitological Museum (JP)
- Tochigi Medical Center (JP)
- Toranomon Hospital (JP)
- Aichi Developmental Disability Center (JP)
- Matsumoto University (JP)
- Mejiro University (JP)
Publication Details
- Journal
- The Journal of Dermatology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1111/1346-8138.70170
- Primary Topic
- Acne and Rosacea Treatments and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sun Pharma