Cystathionine γ‐Lyase‐Dependent S‐Sulfhydration of Smad3: A Novel Target to Alleviate Fibrosis in Systemic Sclerosis
Smad3 S-sulfhydration mediates the antifibrotic effect of CSE in SSc, highlighting it as a critical mechanism and promising therapeutic target.
Authors
- Licong Liu (ORCID: https://orcid.org/0000-0003-0619-7513)
- Yangfan Xiao (ORCID: https://orcid.org/0000-0003-0214-9602)
- Xuan Xiao (ORCID: https://orcid.org/0000-0003-1016-7544)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Ruixuan Zhu (ORCID: https://orcid.org/0000-0001-5630-3615)
- Zehong Song
- P I Zixin
- Yaqian Shi
- Qianyu Yang
- Zhuotong Zeng
- Rong Xiao
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1002/art.70085
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00