A Human Monoclonal Antibody Displays Promiscuous Binding to Multiple Type 1 nsLTP Allergens
IGX-3103 is an example of a human mAb with cross-reactivity to pollen, fruit, and seed type 1 nsLTPs. This observation anecdotally supports the possibility that a few promiscuous mAbs could be driving cross-reactivity.
Authors
- Gage O. Leighton (ORCID: https://orcid.org/0000-0003-4636-0370)
- L.G. Pedersen
- Robert M. Petrovich (ORCID: https://orcid.org/0009-0008-6229-0281)
- Paige Creeks
- Scott A. Gabel
- Geoffrey A Mueller
- Jungki Min
- Derek Croote
- Robert G Hamilton
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute of Environmental Health Sciences (US)
- Nurix (United States) (US)
Publication Details
- Journal
- Journal of Investigational Allergology and Clinical Immunology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.18176/jiaci.1143
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00