Safety, feasibility, and dose‐dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof‐of‐concept studies
PEF-based duodenal regeneration therapy was safe, technically feasible, and associated with durable metabolic improvements over 48 weeks. These findings support further evaluation of duodenal electroporation as a novel, minimally invasive approach for managing T2D.
Authors
- Howard M. McCollister
- Lian Cunningham
- Barham K. Abu Dayyeh (ORCID: https://orcid.org/0000-0001-8084-7225)
- Andrew Storm
- Paul Severson (ORCID: https://orcid.org/0000-0002-5402-7562)
- Bronte A. Holt (ORCID: https://orcid.org/0000-0002-1387-6525)
- Adrian Sartoretto (ORCID: https://orcid.org/0000-0002-7444-4822)
- David O'Neal
- Sujievvan Chandran (ORCID: https://orcid.org/0000-0002-5015-6287)
- Georgina Cameron
- A Thompson
- Elif I Ekinci
- Rhys Vaughan
Institutions
- Cedars-Sinai Medical Center (US)
- Minneapolis Institute of Arts (US)
- The University of Melbourne (AU)
- St Vincent's Hospital Melbourne (AU)
- Bayer (Australia) (AU)
- Michigan Manufacturing Technology Center (US)
- Austin Health (AU)
- Wake Forest University (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1111/dom.70533
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00