Kruppel‐Like Factor 5 Modulates the Nuclear Factor Erythroid‐2‐Related Factor 2/Heme Oxygenase 1 Signalling Pathway to Regulate Vascular Smooth Muscle Cell Ferroptosis in Abdominal Aortic Aneurysm

KLF5 may exert a protective effect by inhibiting ferroptosis and calcium deposition in VSMCs in AAA through regulation of the NRF2/HO-1 signalling pathway.

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Publication Details

Journal
Clinical and Experimental Pharmacology and Physiology
Published
2026-02-01
DOI
https://doi.org/10.1111/1440-1681.70110
Primary Topic
Aortic aneurysm repair treatments
Type
article
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article

Kruppel‐Like Factor 5 Modulates the Nuclear Factor Erythroid‐2‐Related Factor 2/Heme Oxygenase 1 Signalling Pathway to Regulate Vascular Smooth Muscle Cell Ferroptosis in Abdominal Aortic Aneurysm

Guangwei Yang, Chao Weng, Cong Yu
Clinical and Experimental Pharmacology and Physiology
Aortic aneurysm repair treatments
article

Kruppel‐Like Factor 5 Modulates the Nuclear Factor Erythroid‐2‐Related Factor 2/Heme Oxygenase 1 Signalling Pathway to Regulate Vascular Smooth Muscle Cell Ferroptosis in Abdominal Aortic Aneurysm

Guangwei Yang, Chao Weng, Cong Yu
article en

Abstract

KLF5 may exert a protective effect by inhibiting ferroptosis and calcium deposition in VSMCs in AAA through regulation of the NRF2/HO-1 signalling pathway.

Clinical and Experimental Pharmacology and PhysiologyVol. 53(2)
Hangzhou Medical College (CN)
Openalex Percentile: Top 64%
Aortic aneurysm repair treatments
DOISourceOpenAlex
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Kruppel‐Like Factor 5 Modulates the Nuclear Factor Erythroid‐2‐Related Factor 2/Heme Oxygenase 1 Signalling Pathway to Regulate Vascular Smooth Muscle Cell Ferroptosis in Abdominal Aortic Aneurysm — Guangwei Yang, Chao Weng, et al. · Clinical and Experimental Pharmacology and Physiology (2026) | TGRS Research Map | TGRS