Proteomic trajectories in human rotator cuff degeneration: a systematic review of immunohistochemical studies
Cross-sectional human immunohistochemical evidence infers a stage-associated molecular trajectory: inflammatory-hypoxic stress with retained reparative capacity at earlier disease stages to fibrotic-adipogenic failure at later stages. This molecular framework may support future approaches to surgical decision-making and precision therapies.
Authors
- Andrew Zhou (ORCID: https://orcid.org/0000-0001-6656-8123)
- Amr Elmaraghy (ORCID: https://orcid.org/0000-0002-5957-9630)
- Patrick J. Carroll (ORCID: https://orcid.org/0000-0001-7216-1100)
- Dave Osinachukwu Duru (ORCID: https://orcid.org/0009-0005-8396-6146)
Institutions
- University of Toronto (CA)
- University of Cambridge (GB)
- University Hospital Coventry (GB)
- University of Warwick (GB)
- Cambridge School (PT)
- Health Solutions (Sweden) (SE)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13018-026-06735-1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00