Gastric Proton Pumpopathy Associated with Protein Sorting Machinery: A Narrative Review
Defects in sorting machinery lead to gastric proton pumpopathy, causing impaired acid secretion. Thus, protein sorting regulators represent promising therapeutic targets to restore proper pump localization, which is a paradigm shift toward disease-modifying therapies that act upstream of the pump, potentially offering solutions for proton pump inhibitor (PPI)-resistant cases and congenital gastric acid disorders.
Authors
- Aime Niyomugabo
- Leopold Ntakirutimana
- Jean Habineza
- Abdullateef Alagbonsi
Institutions
- University of Rwanda (RW)
Publication Details
- Journal
- Clinical and Experimental Gastroenterology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/ceg.s573016
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00