Curcumin pretreatment enhances the capacity of BMSC exosomes to attenuate renal ischemia-reperfusion injury by ferroptosis suppression via miR-16-5p/Smad3/Mb axis
Our research indicates that curcumin preconditioned BMSC exosomes can exert a therapeutic effect on RIRI by inhibiting cellular ferroptosis. The primary mechanism behind this effect involves curcumin increasing the expression of miR-16-5p by modulating CYP1B1 activity, and cur-exo promoting the alleviation of ferroptosis in TCMK-1 cells through the miR-16-5p/Smad3/Mb axis. This study provides a new strategy for enhancing the biological functions of exosomes and presents new targets and ideas for the treatment of RIRI.
Authors
- Yifan Mei (ORCID: https://orcid.org/0009-0002-5389-2666)
- J. Chen
- Bingyi Chen (ORCID: https://orcid.org/0000-0001-9525-2021)
- Weiyi Wang (ORCID: https://orcid.org/0000-0002-1947-3356)
- Zekun Shen
- Shaoying Lu (ORCID: https://orcid.org/0000-0001-8289-2177)
- Shuang Liu
- Hui Cai
- Ziyang Peng
- Liwei Zhang
- Kai Li
Institutions
- University of Illinois Chicago (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s13287-026-04931-8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00