MERGE: Mammogram-Enhanced Representation via Wavelet-Guided CNNs for Computer-Aided Diagnosis of Breast Cancer

The early and accurate identification of breast cancer is a significant healthcare issue, largely because the traditional machine learning approaches rely on handcrafted features that are unable to fully capture the spatial and textural complexity found in mammograms. Even with the advancements made possible through deep learning and improvements in diagnostic performance, most computational-aided diagnosis (CAD) systems based on Convolutional Neural Networks (CNNs) still only rely on single-domain features, normally spatial features, while neglecting some important spectral and spatial–spectral features, leading to limitations in generalisability, redundancy, and loss of performative interpretability. Inspired by these limitations, this research proposes MERGE, a novel CAD framework that combines spatial, spectral, and spatial–spectral information—all part of a single multistage architecture taking advantage of three fine-tuned CNN models (ResNet-50, Xception, and Inception). This system utilises Discrete Stationary Wavelet Transform (DSWT) to enhance spectral–spatial features; Discrete Cosine Transform (DCT) to fuse the features optimally, resulting in enhanced spatial and spatial–spectral representations; and, finally, Non-Negative Matrix Factorisation (NNMF) for reduced-dimensional features. Finally, the Linear Discriminant Analysis (LDA), support vector machine (SVM), and k-nearest neighbours (KNN) classifiers provide a robust diagnosis. Using the INBreast and MIAS datasets in evaluations of the experimental research design, evaluation metrics of accuracy, sensitivity, specificity, and AUC were around 99%, with performance surpassing state-of-the-art paradigms. The findings of the suggested MERGE indicate significant promise as a dependable and effective diagnostic tool, enhancing the consistency and interpretability of breast cancer screening results.