Whole Exome Sequencing Revealed Rare Variants in BRCA2, RAD51D, FANGC, CYP24A1 Genes in Breast/Ovarian Cancer Patients from a Small Buryat Ethnic Group
For the first time, rare germinal variants in the BRCA2, RAD51D, FANGC, CYP24A1 genes were detected in a small Buryat ethnic group. Our data are consistent with existing data showing that variants in the RAD51D gene may be involved in the pathogenesis of breast/ovarian cancer. We also showed that the Mongolic-speaking Buryat populations exhibited strong genetic resemblance to those of Chinese.
Authors
- Anna Ivanova (ORCID: https://orcid.org/0000-0002-2454-1288)
- Evgeny Choynzonov Evgeny Choynzonov
- O. V. Kollantay
- Т. А. Дронова (ORCID: https://orcid.org/0000-0003-3009-2404)
- Polina Gervas (ORCID: https://orcid.org/0000-0003-0051-8814)
- Mikhail A. Buldakov
- Nadezda Cherdyntseva
- Alexey Molokov
- Liliya Molonova
- Alexey Zarubin
Institutions
- National Research Tomsk State University (RU)
- Buryat State University (RU)
- Research Institute of Medical Genetics of Russian Academy of Medical Sciences (RU)
- Tomsk National Research Medical Center (RU)
Publication Details
- Journal
- Asian Pacific Journal of Cancer Prevention
- Published
- 2026-02-01
- DOI
- https://doi.org/10.31557/apjcp.2026.27.2.651
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation