Decoding Hypervirulence in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> : Genomic and Phenotypic Profiling Reveals Capsular Polysaccharide as a Key Driver of Pathogenicity
We conclude that clinical application of the term "hv-CRKP" requires prudent validation and emphasize the urgency of developing biomarkers to precisely identify truly hypervirulent CRKP strains.
Authors
- Sai Tian (ORCID: https://orcid.org/0000-0002-5309-240X)
- Jiajie Wang (ORCID: https://orcid.org/0009-0008-8016-1416)
- Shuanghong Yang
- Min Qiu (ORCID: https://orcid.org/0000-0002-7373-2355)
- Meilin Wu
- Li Xu
- Yeting Zhu
- Lei Dou
- Jiayang Li (ORCID: https://orcid.org/0000-0001-9245-0209)
- Xiuwen Wu
- Jianan Ren
- Wenqi Wu
- Zhitao Zhou
- Zhiwu Hong
- Rui Ma
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jinling Institute of Technology (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1093/infdis/jiag075
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00