Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica
Genetic predisposition beyond HLA-DR4 alone is required for the immunological manifestations that lead to c-silica mediated inflammatory arthritis. These findings provide novel insights into the relationship between mucosal exposure and RA pathogenesis.
Authors
- Lisa Janssen (ORCID: https://orcid.org/0000-0002-8687-6745)
- Jessica Mayeux (ORCID: https://orcid.org/0000-0001-7335-6807)
- Peter Hoet (ORCID: https://orcid.org/0000-0002-0292-6603)
- Steven Ronsmans (ORCID: https://orcid.org/0000-0002-6767-2691)
- Dwight H. Kono
- Caroline de Ocampo
- Manosij Ghosh
- K. Michael Pollard
Institutions
- Scripps Research Institute (US)
- Scripps Health (US)
- Department of Public Health (MM)
- Department of Public Health (US)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1186/s12989-026-00662-z
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas Southwestern Medical Center
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering
- National Institutes of Health