Editorial: Molecular and functional profiling in breast cancer: implications for hereditary and sporadic cases

Complementing hereditary perspectives, this Research Topic includes two contributions 42 addressing molecular events that shape behaviour and immune interactions in sporadic BC. 43 Benthami et Yet the substantial time, cost, and analytical effort required for these advanced approaches raises the 79 question of whether they are truly justified by the potential for better patient treatment or represent an 80 unsustainable burden for resource-limited hospitals. As molecular technologies continue to expand, 81 bridging the gap between genomic discovery and clinical implementation remains a critical priority. 82The contributions assembled here reinforced the need for collaborative research spanning laboratory 83 sciences, clinical oncology, immunology, bioinformatics, and ethics. We hope that this collection will 84 inspire further interdisciplinary efforts to improve outcomes for individuals affected by BC and to 85 advance the promise of precision medicine. 86 1Eliminato: A complementary perspective is provided by Zheng et al., who describe a case report with a rare presentation of symptomatic bone marrow metastasis in a patient with metastatic TNBC. The authors emphasized that in TNBC patients, especially those presenting with cytopenia, biopsy of bone marrow metastasis should be performed to have a definitive diagnosis, even if conventional imaging is without significant abnormalities. This case also emphasizes the clinical urgency of recognizing biologically aggressive disease patterns that may benefit from intensified systemic therapy and supportive care such as nutrition