Development and Validation of a Time‐Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug‐Resistant Tuberculosis

This nomogram, integrating C<sub>min</sub> with baseline clinical factors, enables early identification of patients with DR-TB at high risk for hematotoxicity and could guide pre-emptive interventions. However, external validation is required to confirm its generalizability before widespread clinical implementation.

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Publication Details

Journal
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Published
2026-02-09
DOI
https://doi.org/10.1002/phar.70109
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
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article

Development and Validation of a Time‐Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug‐Resistant Tuberculosis

N Chu, Zhongquan Liu, Wenjuan Nie, Wenjie Qi et al.
Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
Tuberculosis Research and Epidemiology
article

Development and Validation of a Time‐Dependent Nomogram for Predicting Hematological Toxicity Risk During Linezolid Therapy in Drug‐Resistant Tuberculosis

N Chu, Zhongquan Liu, Wenjuan Nie, Wenjie Qi, Wenhui Shi, Yang Yang, Wenqiang Zhou, Yu Lu, Hui Zhu, Qingfeng Wang
article en

Abstract

This nomogram, integrating C<sub>min</sub> with baseline clinical factors, enables early identification of patients with DR-TB at high risk for hematotoxicity and could guide pre-emptive interventions. However, external validation is required to confirm its generalizability before widespread clinical implementation.

Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyVol. 46(3)
Beijing Chest Hospital (CN), Beijing Friendship Hospital (CN)
Good health and well-being
Openalex Percentile: Top 62%
Tuberculosis Research and Epidemiology
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