Solvent-Free α-Arylation Reaction of Ketones with (Hetero)aryl Chlorides by <i>N</i> -Heterocyclic Carbene–Palladium Complex (SIPr) <sup>Ph2</sup> Pd(cin)Cl
A green and mild palladium-catalyzed solvent-free α-arylation reaction of ketones was disclosed for the first time. Using the robust <i>N</i>-heterocyclic carbene-palladium complex (SIPr)<sup>Ph2</sup>Pd(cin)Cl, (hetero)aryl chlorides and ketones were able to generate monoarylation products in excellent yields under solvent-free conditions, with a total of 41 examples. Furthermore, the protocol has been demonstrated to be suitable for multigram-scale preparation with a high yield.
Authors
- Liqin Qiu (ORCID: https://orcid.org/0000-0003-1703-3530)
- Liqun Hu
- Jia‐Sheng Ouyang (ORCID: https://orcid.org/0000-0002-8881-3676)
- Xiaoling Wang
- Huizhen Jiang
- Ruiyong Luo
Institutions
- Sun Yat-sen University (CN)
- Changsha Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1021/acs.joc.5c02510
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00