Development of an Oral Anticoagulation Strategy for Permanent Artificial Lung Support

These results demonstrate that rivaroxaban has artificial surface anticoagulation efficacy similar to that of heparin at dosages that are feasible for oral administration in humans. Future studies will evaluate rivaroxaban anticoagulation using a 10-d full-scale ovine ECMO model.

Authors

Keith E. Cook
Yeahwa Hong (ORCID: https://orcid.org/0000-0001-9963-6970)
Umar Nasim (ORCID: https://orcid.org/0000-0002-9171-541X)
Helen Scala
Patrick Iyasele
Abigail Gredell
Suji Shin (ORCID: https://orcid.org/0000-0002-8323-9919)
Kelly Strong
Adel Akhavanmalayeri

Institutions

University of Pittsburgh Medical Center (US)
Carnegie Mellon University (US)

Publication Details

Journal: Transplantation
Published: 2026-02-09
DOI: https://doi.org/10.1097/tp.0000000000005617
Primary Topic: Mechanical Circulatory Support Devices
Type: article
Field-Weighted Citation Impact: 0.00

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article

Development of an Oral Anticoagulation Strategy for Permanent Artificial Lung Support

Keith E. Cook, Yeahwa Hong, Umar Nasim, Helen Scala et al.

Feb 9, 2026

Transplantation

Mechanical Circulatory Support Devices

article

Development of an Oral Anticoagulation Strategy for Permanent Artificial Lung Support

Keith E. Cook, Yeahwa Hong, Umar Nasim, Helen Scala, Patrick Iyasele, Abigail Gredell, Suji Shin, Kelly Strong, Adel Akhavanmalayeri

February 9, 2026article en

Abstract

These results demonstrate that rivaroxaban has artificial surface anticoagulation efficacy similar to that of heparin at dosages that are feasible for oral administration in humans. Future studies will evaluate rivaroxaban anticoagulation using a 10-d full-scale ovine ECMO model.

TransplantationVol. 110(4)

University of Pittsburgh Medical Center (US), Carnegie Mellon University (US)

Zero hunger

Openalex Percentile: Top 64%

Mechanical Circulatory Support Devices

DOI Source OpenAlex

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Development of an Oral Anticoagulation Strategy for Permanent Artificial Lung Support — Keith E. Cook, Yeahwa Hong, et al. · Transplantation (2026) | TGRS Research Map | TGRS